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Publications

2024

 

Randall S. Carpenter, Maria Maryanovich. Systemic and local regulation of haematopoietic homeostasis in health and disease. Review article. Nature Cardiovascular Research. 2024 June 12 doi: 10.1038/s44161-024-00482-4

 

Maria K. Lagou, Dimitrios G. Argyris, Stepan Vodopyanov, Leslie Gunther-Cummins, Alexandros Hardas, Theofilos Poutahidis, Christos Panorias, Sophia DesMarais, Conner Entenberg, Randall S. Carpenter, Hillary Guzik, Xheni Nishku, Joseph Churaman, Maria Maryanovich, Vera DesMarais, Frank P. Macaluso, George S. Karagiannis. Morphometric Analysis of the Thymic Epithelial Cell (TEC) Network Using Integrated and Orthogonal Digital Pathology Approaches. BioRxiv 2024.03.11.584509; doi:10.1101/2024.03.11.584509. Preprint.

 

2023

 

Marchand T, Akinnola KE, Takeishi S, Maryanovich M, Pinho S, Saint-Vanne J, Birbrair A, Lamy T, Tarte K, Frenette PS, Gritsman K. Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury. bioRxiv. 2023 Jan 13;2023.01.12.523842. doi: 10.1101/2023.01.12.523842. Preprint.

 

Li H, Kazmi JS, Lee S, Zhang D, Gao X, Maryanovich M, Torres L, Verma D, Kelly L, Ginzburg YZ, Frenette PS, Manwani D. Dietary iron restriction protects against vaso-occlusion and organ damage in murine sickle cell disease. Blood. 2023 Jan 12;141(2):194-199. doi: 10.1182/blood.2022016218.

 

2022

 

Maryanovich M, Ito K. CD36-Mediated Fatty Acid Oxidation in Hematopoietic Stem Cells Is a Novel Mechanism of Emergency Hematopoiesis in Response to Infection. Immunometabolism. 2022;4(2):e220008. doi: 10.20900/immunometab20220008. Epub 2022 Mar 14.

 

2021

 

Wei Q, Pinho S, Dong S, Pierce H, Li H, Nakahara F, Xu J, Xu C, Boulais PE, Zhang D, Maryanovich M, Cuervo AM, Frenette PS. MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells. Nature Communications. 2021 May 4;12(1):2522. doi: 10.1038/s41467-021-22749-1.

 

Zahalka AH, Brodin NP, Maryanovich M, Wang X, Watts KL, Pinho S, Guha C, Frenette PS. Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation. Scientific Reports. 2021 Mar 22;11(1):6571. doi: 10.1038/s41598-021-86067-8

 

Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A. Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nature Communications. 2021 Jan 27;12(1):608. doi: 10.1038/s41467-020-20801-0

 

2020

 

Demir IE, Reyes CM, Alrawashdeh W, Ceyhan GO, Deborde S, Friess H, Görgülü K, Istvanffy R, Jungwirth D, Kuner R, Maryanovich M, Na'ara S, Renders S, Saloman JL, Scheff NN, Steenfadt H, Stupakov P, Thiel V, Verma D, Yilmaz BS, White RA, Wang TC, Wong RJ, Frenette PS, Gil Z, Davis BM. Clinically Actionable Strategies for Studying Neural Influences in Cancer. Cancer Cell. 2020 Jul 13;38(1):11-14

 

2019

 

Hanoun M, Arnal-Estapé A, Maryanovich M, Zahalka AH, Bergren SK, Chua CW, Leftin A, Brodin PN, Shen MM, Guha C, and Frenette PS. Nestin+ NG2+ cells form a reserve stem cell population in the mouse prostate. Stem Cell Reports. 2019 Jun 11;12(6):1201-1211

 

Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka AH, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma'ayan A, Greally JM, Frenette PS. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells. Nature Cell Biology. 2019 May;21(5):560-567

 

2018

 

Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, Wei Q, Wang X, Ciero P, Xu J, Leftin A, Frenette PS. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nature Medicine. 2018 May 7; 24:782–791

 

Maryanovich M, Takeishi S, Frenette PS. Neural Regulation of Bone and Bone Marrow. Cold Spring Harbor Perspect Med. 2018 Mar 2. pii: a031344

 

2017 and prior

Zahalka AH, Arnal-Estapé A, Maryanovich M, Nakahara F, Cruz CD, Frenette PS. Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science. 2017 Oct 20; 358(6361):321-326

 

Maryanovich M, Frenette PS. T-Regulating Hair Follicle Stem Cells. Immunity. 2017 Jun 20; 46(6):979-81

 

Maryanovich M, Frenette PS. A Time Bomb for Leukemia. Cell. 2016 Apr 7; 165(2):262-3

 

Maryanovich M, Zaltsman Y, Ruggiero A, Goldman A, Shachnai L, Zaidman SL, Porat Z, Golan K, Lapidot T, Gross A. A MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nature Communications. 2015 Jul 29; 6:7901

 

Hanoun M*, Maryanovich M*, Arnal-Estapé A*, Frenette PS. Neural Regulation of hematopoiesis, inflammation and Cancer. Neuron. 2015 Apr 22; 86(2):360-73. Review. *Co-first author

 

Gross A, Zaltsman Y, Maryanovich M. The ATM-BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism. Cell Death and Differentiation. 2016 Jan; 23(1):182

 

Maryanovich M, Gross A. A ROS rheostat for cell fate regulation. Trends in Cell Biology. 2013 Mar; 23(3):129-34

 

Maryanovich M, Oberkovitz G, Niv H, Vorobiyov L, Zaltsman Y, Brenner O, Lapidot T, Jung S, Gross A. The ATM-BID Pathway regulates quiescence and survival of haematopoietic stem cells. Nature Cell Biology. 2012 Mar 25; 14(5):535-41

 

Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, Gillissen B, Daniel PT, Jimenez E, Walsh S, Koehler CM, Roy SS, Walter L, Hajnóczky G, Gross A. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nature Cell Biology. 2010 Jun; 12(6):553-62

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