Welcome to the Maryanovich Lab!
Welcome to the Maryanovich Lab at Albert Einstein College of Medicine! The lab was established in February of 2022 and is headed by Dr. Maria Maryanovich, Assistant Professor in the Department of Cell Biology. Our lab is also part of two Einstein Institutes: 1) the Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine, and 2) the Cancer Dormancy and Tumor Microenvironment Institute.
Our goal is to understand the cellular and molecular regulators of hematopoietic stem cells (HSCs). HSCs are long-lived stem cells responsible for generating billions of red blood cells, white blood cells, and platelets. These critically important cells reside within the bone marrow in a microenvironment ("niche") that supports their survival, proliferation, and differentiation. Improper control of HSCs results in a wide range of clinical conditions including anemia, thrombocytopenia, immune dysfunction, and hematological malignancies.
Lab projects cover a wide scope of hematopoiesis biology, from circadian regulation to reactive oxygen species and beyond. Teasing apart the interactions between HSCs and other cells in the bone marrow niche is of fundamental importance to our lab. We hope that our novel discoveries will provide a roadmap for the development of treatment strategies to help millions of individuals and their families suffering from hematological diseases. As is the motto of Albert Einstein College of Medicine: Science at the Heart of Medicine.